I have killed 1 deer with that bullet in my Casull. Front of the chest at 25 yards. He ran about 35 yards and folded up. Never recovered the bullet. Killed him quick and damage to the lungs was tremendous. I too was getting great accuracy with the bullets.
My Super Redhawk wears a Burris 2-7 with the posi-lock option. It has an extra screw that locks the reticle in place after you sight in. The 454 destroyed the first scope I put on it after a couple hundred rounds.