After many years of carrying a revolver or other DA pistol, it was a little unnerving to holster and carry around a 1911 cocked and locked. So, what I did was (always remembering that I had an unloaded pistol on me so not to get into a bad situation) I carried it around empty for about a week. When alone or in the back yard, I'd practice drawing and thumbing off the safety. When I was totally comfortable that I wasn't going to remove vital organs, I loaded it and never looked back.
BTW, in my opinion, thumbing off the safety is no more difficult than doing so with other pistols. And I'm a firm believer that if the firearm has a manual safety, it should be used!!!!