Defensive ammo: .45acp
According to statistics compiled by the us justice dept. The federal 230 grain "hydra-shok" is a top-tier performer. However, hornady, winchester, speer, remington, & cor-bon would all be acceptable for defending self, home, & hearth.
Mostly, it depends upon what your pistol will reliably feed 100% of the time & what your barrel groups the best @ 25 yards shooting from a bench-rest, to determine what your launching platform prefers.
You question is one of those we frequently on this forum, that is virtually unanswerable because forum contributors will have a personal opinion based on experience or shooting bias. Remember to keep an open mind when recommendations began pouring in from the membership.
Good luck in your personal quest for the "holy grail" of factory ammo for your personal needs.
Guru1911