Redford1,
I think your own link is an example. The manual can probably be downloaded with the free demo
from NECO. Otherwise you need to ask specific questions of more experienced users to get answers.
What QuickLOAD does best is get you relative change information when you change a parameter, like seating depth or powder burn rate. If it says the pressure changed 5%, then, even though the absolute pressure is different, the 5% change is very close. Occasionally it is right on actual measured numbers, but more frequently it is off by some percentage compared to published data. This is often due to component and powder lot differences more than anything else. I've seen .223 data for which a change from mild to magnum primer raised velocity 5% and peak pressure probably almost 12%.
Extrapolation can, to a degree, be checked in QL by percent change if you first get a good match to published pressures.
At the last NRA Annual Meeting, I spent some time talking to Dr. Ken Oehler, who has been in the commercial ballistics equipment business for a long time. His opinion was that pressure measuring was difficult to have high confidence with beyond about 5% of absolute, so you have that sort of reality allowance to make even to what is published as a measurement. If you look at
this Somchem data, you can see velocity changing almost 2% (60 fps out of 3,000 fps) just with powder lot variation. Average pressure, as I said, varies as the square of velocity, so that would be about a 4% variation in average pressure and probably closer to 5% in peak pressure. Even the best government super computer running the most sophisticated and detailed models could not, therefore, be counted on to make a prediction any more precise than that without having been adjusted to match the particular powder lot you are using and ll the other components.
The bottom line is that when powder variation and measuring limitations are taken into account, it's pretty likely that reality varies by 10% from the ideal with some frequency and maybe a bit more when individual gun differences are taken into account. SAAMI allows individual round pressure measurements to vary by over 18% in the extreme. The CIP limits it to 15%, but you can get the idea from both those numbers that variation from the ideal at these percentages are not out of the question and so you can't expect any prediction to do better than that in all instances.
Bottom line, QuickLOAD will usually give you real velocity within 5% but occasionally can only get within 10% for some combination. Corresponding pressures would be within about 12% and worst case 25% in error, though I don't see something like that very often. I know it sounds large, but 25% is actually not too far off from what reducing charge weight 10% does for some powders. But check the real data for confirmation. With some chronograph feedback you can narrow it considerably. Once you have it narrowed for a lot of powder and gun you own, you can predict things much more closely.