The above post is right on. Generally the 115 gr. HP expands rapidly, and would be a good choice for home defense if you were concerned with over-penetration.
The 147 gr. does not always expand in the HP, because of the heavy wt. for caliber, but good penetration.
The 124-127 gr. gives good expansion, and penetration in the HP. I personally use Win. Ranger 127 gr. SXT HP + P +. But there are many great choices as pointed out. In my opinion this is the best choice for general SD carry.
What ever you decide don't use hardball for self-defense. It will over penetrate and has a poor record as a manstopper, but it's good for practice. There is a long history of this.
Make sure to shoot whatever you decide on to see if it will function in your gun and shoot to POI. Good Luck, Eagle