Is there a cartridge where 4350 is recommended that it does not work well in might be a better question
I have a 243 Win and I've tried all sorts of different powder/bullet combinations in it. I've used 4350, 4831, 7828, 4064, R17, and Superformance and I keep coming back to 4350 as the most accurate powder for it with all bullets tried. I've settle on using 80 grn Barnes TTSX and IMR4350, and when I do my part it'll shoot itty bitty sub .5 MOA groups.