It would work
its more of a CQB thing at that point, though if its made well you would still be able to hunt to say 200 yards or so. I have never made a shot on an animal that was further than 300 yards, while i could i just havent had any reasonable excuse not to get closer or im just that good at hiding and the animals are dumb.
You will loose some velocity due to the barrel being short and it will be a bit louder. I will still kill bambi and wilber though (provided wilbur is not 400 lbs)
personaly a short barrel kind of defeats the purpose of a 6.5 grendel build, that load has some good potential for range and accuracy. IMO