To answer your question simply ,yes, but deer can be taken with a 22lr also, is it ethical? NO, i used a 44mag taurus with a scope loaded to the max last year and killed a doe at 40yards, i will not shoot at a deer past 50yards [with a handgun], the loads you can put in a remmie 1858 or 45long colt are not even close to a modern smokeless revolver, save your remmie for small game and target shooting, just my opinion, pghrich