There is a major difference. The extreme wrist snapping recoil of the 454 is a wake up. The 500 S&W I shot actually pushes straight back into your shoulders. I felt like I had bumped into someone. It isn't unpleasant and no CTS problems. The S&W 500 is more of a whole body experience. I was not shaken, stirred, cut, stapled or spindled. I am 5'11" and 230 lbs. YMMV