Experts have been looking at this matter for some time, and have some interesting findings. The original black powder guns, fired with duplicates of the original black powder ammo do fail sometimes. (they are, after all, very old) They have a calculated rate of failure, drawn from the actual observed failures. (not talking just blow ups, but things like frames cracking, etc)
SO, this does happen.
They have also found that the same guns (as a group) fail at a higher rate when fired with "safe" smokeless powder loads. (again, not dangerous blow up fails, but structural fails that render the gun unsafe to use again)
They say black powder only for these guns, not because they love black powder, but because they love the old guns and their experience says the old guns will last longest shooting only black powder.
In modern reproductions of the old guns (C.Sharps is one) smokeless powder loads in the proper pressure range are no concern at all.