I'm not Glock's biggest fan, and much prefer the 1911 in fact. That being said, for this powerful cartridge, I'd have to go with Glock. This, because of the Glock's greater slide mass/weight. The Glock 21 has the heaviest slide of any service size pistol I have encountered. Though strength is not the primary issue, I suspect impressive strength comes with the G21 slide mass. I know manufacturers and shooters try to make up for marginal slide mass in some pistol/cartridge combinations by using heavy springs, dual springs, buffers, barrel weights, compensators, etc. I would much rather just have a pistol with sufficient slide mass and forego all the other things I mentioned in achieving a pistol that is both reliable and durable......ymmv