The huge selection of ammo today, makes this a difficult question to answer. There are .45 colt loads out there from mild (cowboy action) to wild (buffalo Bore) and there are reduced .44 mag loads, and .44 special loads mild, to .44 mag wild (buffalo bore again). But If you are used to standard velocity .45 colt ammo, the full power .44 mag will be a very big step up in recoil and muzzle blast. If you go to a .44 mag, I would suggest that you start with Buffalo Bore's heavy .44 special load first. After shooting this ammo, you can decide if you still want to go higher and get a taste. of the full power stuff. If you reload....then you can assemble handloads that meet your comfort level. If you shoot factory loads only, there is still a wide spectrum of loads out there for the .44special/mag. I'm sure you could find some factory ammo that would meet your needs.