I think Sam was trying to say that the two cartridges are remarkably similar, which they are. Off-the-shelf .44spl FMJ (not cowboy loads and not exotic stuff) and off-the-shelf .45ACP FMJ are practically the same, ballistically. Virtually the same size bullet (.4x), virtually same weight (230 or 240), virtually same speed (8xx fps).
"Defense" loads are also very similar in the two rounds. You can get cowboy loads for the .44spl that you can't get for the .45ACP. They're even slower--and smoky, stinky, and lead-y to boot.
Now, if you handload, that's where .44spl gets interesting.