Varies by pistol
I have 4 different .45 autos that I shoot target with. I do all of the accuracy testing at 50 yards. I have shot semi-waddcuters for years and I almost always do better with 200s than 185s. I have a good load for my two Springfields but it is just okay in my Dan Wesson Pointman 7. The Springfield will shoot 5-shot groups just under 2" but the same load in the Dan Wesson will stretch over 3". But another load will do around 2.25" out of the Dan Wesson but around 4" with the Springfield at 50. What I am saying is there is no one answer. I have tested extensively with Bullseye, Titegroup, WST, WSF, HS6, N310, AA#2, AA#5, WW 231, Clays and some I am sure I forgot.
The most accurate for me was 3.7 WST with a 200 SWC that is around 624 FPS. Remember you are shooting these with one hand so you want to make enough surplus energy that even if you get sloppy and your grip loosens some, the gun still cycles as I use a standard 16 pound spring. I have taken them down into the 550 range but I have had some stoppages there with a limp grip. The best 185 load I found is in the 742 FPS range. Just in the last month I decided to try some EIC matches and in them you have to shoot "hardball." Okay so I bought some Winchester Super-X 230 FMJ and thought I am good to go. These things were all over the paper at 50 yards. I couldn't find any 230 bullets to load so I pulled a couple of hundred of the Winchester and loaded them with different powders until I tried Clays. That load grouped at least 3X smaller than the factory ammo with the velocity at 708 FPS where the factory Winchester was in the 830 range. Since then I found some Sierra 230 FMJ Tournament Masters and they are very accurate but still did the best with Clays. All of the powders I tested shoot okay but some clearly are better than others in certain applications. However I cannot over emphasize the need to get a load for your gun because I have yet to find a perfect load that does everything well in all guns. Hope this helps.