I own two S&W .45s, an old Hand Ejector Mk. II coverted from .455, and a modern Model 22. I can see no advantage whatsoever to a .45 ACP revolver when compared to a 1911. I enjoy shooting guns of different types, but if I were doing anything requiring a .45 that didn't limit me to a revolver (competition), I'd choose a 1911 every time.
If I were going to buy a new .45 today, one that appeals to me very much is the Colt New Frontier. I'd want it chambered in .45 Colt, with a spare ACP cylinder. With a 7.5" barrel and a good trigger, I might be able to shoot it more accurately than any of my autos, and that would be an advantage.