Measure your cylinders' chambers' throats, our forcing cone and your barrel diameter (in other words, slug your bore).
Once you know those dimensions, you have the information to get your answer.
The relationships (as I understand it) for lead bullets are:
The chamber throats, if the same size or slightly smaller than your bullet diameter will swage bullets down. As they emerge from the throat and enter the forcing cone, they may upset (due to the pressure) to a little bit larger diameter. As the bullets engage the rifling, it is important that the bullet diameter completely fill the bore. Barrel erosion and leading may occur if the bullet does not fill and seal the bore, as the hot gasses going past the side of the bullet melt the lead and may erode the barrel.
With jacketed bullets, the relationships are similar, but I don't completely understand it yet.
What has been said earlier in this thread is true, too. You don't want to drive a bullet harder than it can stand without coming apart. Rifle shooters have sometimes been able to push bullets so hard that they disintegrate in the air a short distance from the muzzle (usually from centrifugal force). Stripping the plating from a plated bullet or blowing the core out of it may well leave a partial barrel obstruction. So, NEVER drive a bullet faster than it was designed to go, even if the gun can stand the pressure, the bullet may not.
So, slug your bore and your throats. With modern guns (few manufacturers are producing .454" barrels because they know 45ACP conversions are popular for many 45 Colt-chambered revolvers) often sporting .451" barrels you are likely just fine. But it is best to be sure.
Good luck and thanks for asking our advice.
Lost Sheep
Note: I am no gunsmith.