I've shot a bunch of .400 Cor-Bon and .40 Super through my G21. Have shot .400 Cor-Bon through my compensated Gold Cup. The point is, I'm pretty experienced with hi-vel loads. I shot some .45 Super through a friend's G21, equipped with the same threaded, compensated Accu-Match barrel as my compensated barrels, except, of course, his is .45 ACP. We had a great deal of difficulty getting the .45 Super to feed. The slide speed was such that rounds weren't being picked up from the mag. We tried several different mags. We're using a 22# spring, but will go to a 24#. Also, will try stronger mag springs.
Your Springfield has all those bugs worked out. The .45 Super will no doubt work fine in your pistol. We were shooting 230gr. Golden Sabers (which I hate, due to the "driving band") and 230gr. Hornady XTP's. The Hornady's are easier to load and are probably more effective for hunting. I was using 14 gr. of AA #7.
I forgot my ear protection on one shot, having been distracted by the jams. Won't ever let that happen again!!