Those big heavy bullets travel like a freight train.
That's why they work so well.
"Overpenetration" is one of my personal buttons. I can see where it is a significant concern for some people, and for police agencies, but I'm not them.
I don't live in a crackerbox with people close on all 6 sides. I'm not a dept where I have to worry about lawsuits from (possibly) dozens of officer involved shootings every year. SO, for ME its a low priority, one I balance against the risk of the bullet not penetrating ENOUGH.
The Famous FBI Miami shoot out, where a 9mm bullet, that met all the penetration requirements, "failed" to stop the bad guy immediately. It did cause a lethal wound, but stopped just short of reaching a point which would have incapacitated the bad guy right then.
SO, I believe that a bullet that does not have the capability of complete penetration cannot be fully relied on to have enough penetration for all possible situations.
This is my personal opinion and each person has to decide for themselves what their priorities are.
For myself, and only myself, I would choose a bullet that goes all the way through, from every possible angle, so as to be certain it has enough penetration to go to (and through) where it needs to go.
That being said, I won't tell you not to choose a bullet "less likely" to "over penetrate". If you have confidence that its performance will be enough to save your personal posterior, then by all means, use it!
There is no magic bullet, and there is no free lunch. For every thing you get, you have to give up something. Up to each of us to decide what's more important to have and what's more important to give up.