Lets be clear about something, do you have a Lyman manual that lists loads for the Hornady 250gr XTP bullet, or does it list loads for "250gr jacketed"?
The XTP is a specific bullet, with its own characteristics, jacket hardness, bearing surface, etc. The maker worked up loads for it. If you follow their recommendations you should be fine.
That being said, I've been loading .45 Colt for a long time, had my days of playing with the heavy loads, and settled on a load that wasn't quite as much, (Ruger Blackhawk) I load to the max listed in my old Lyman manual for a COLT SAA, which is significantly higher than the loads you are looking at.
Different loading books use different test guns and components. Where they stop is either where they got signs of excessive pressure, or SAAMI max pressure, or where the performance of the load is so poor it doesn't justify going any further with it. It's NOT the blow up limit of the gun.