I experimented pretty extensively with various cartridges in various barrel lengths over a chronograph and Pathfinder45's numbers are a good estimate of what you can expect to see. With slower burning powders, I have seen more than 300 fps in some cases but 300 is a decent rule of thumb.
After the testing, my take home message was that whatever the fastest velocity load in a rifle is, that will also be your fastest velocity load in the revolver. There is no optimizing for the longer barrel. In other words, I just looked at the Hodgdon website and the fastest velocity .45 Colt, 225 grain load is with Lil Gun powder. If you test all the powders on that site with the max loads in both rifle and pistol, you will find that Lil Gun gives you the most velocity out of either a rifle or pistol. And the powder that gives you the most velocity will be the slow burning powder.
I am not sure that is clear, maybe it's too early for me.