The following load works well in my NV in .45 LC...and I feel it's a safe load. You should work up to it for your gun, after consulting a GOOD manual and considering all the pressure implications.
Lyman mold #452190 (RNFP: weight = 260 grains) using WW alloy, sized 0.454" and lubed with 50-50 alox/beeswax, 7.2 gr of Winchester 231 gives me 854 fps and an ES of just 27 fps in my NV with 4-5/8" bbl.
I use Winchester LP primers and brass and seat the bullet to 1.600" COL with a stout, roll crimp on the ogive. This load is good for less than 2" at 25 yds from my gun and it's more accurate than the standard old load of 8.0 gr of Unique for me. That Lyman bullet matches the original contour of the .45 bullet, and also for Remington's current lead bullet offering.
HTH's Rod