If you want a handgun with a 4" or shorter barrel that you can carry on your belt everywhere you go in the wilderness, what else are you going to buy? You would tear a S&W 625 to pieces if you tried to get similiar ballistics. The .500 is pretty cool but it is pushing my idea of a "belt gun."
I see it as a "super .45 Colt" myself. I want to buy one but I probably won't shoot much .454 in it. But I will shoot .45 Colt loaded just as hot as I please. And I won't worry about whether I'm damaging the gun! My wrists and elbow will give out before that revolver! And yet it should be a real pussycat with 1000 fps 250 grain Keith bullet loads. That's versatile and yes, even practical.