A lot of people seem to like Bullseye for .45acp target rounds. IIRC, loads from 3.8-4.0 grains seems to pop up regularly.
I have not loaded using Bullseye, but until I can put five rounds into 3" or so at 25 yards, I don't think I'm good enough to notice the difference in accuracy between powders (I'm working on it).
I have loaded .45acp with W231, Unique and Green Dot. Since I use a Dillon, and have yet to get Unique to meter consistently throught it (not an uncommon situation, from what I read) that means that (for me) Unique is only suited to a single stage with individually dipped and weighed loads.
My friend uses Bullseye on my Dillon to produce .38 Spl loads by the thousands. No worries at all.