Oh well, it's late and totally agree with the majority. The .357 will be easier to handle-as far as grip size and recoil, especially with .38 spl for practice. Also, if your out on a walkabout, much easier to carry on the belt, or in a pack. Although you mentioned primary uses being home defense and range shooting, since it might be the 'one' for a while, might as well get something better suited to use as a field gun, plinker, and HD etc. .44 as some have noted is a bit specialized. Also to learn with, or teach others a mixed .357/.38 is better...often the blast or frame size on a .44 will cause kids/new to firearms or wives/novias etc...to quit or get quite a flinch problem going.
After you get some practice and get used to it/or will be inclined to keep loaded and secure somewhere...might consider buying some magsafes or the like, and load the 1st few chambers with those, and the remaining with usual HP's. A good compromise if there might be a concern about overpenetration.
After you get proficient in handling and etc... Might make up some clearly marked inert loads and practice charging with the speedloader and dumping the 'empties', especially until you can do so without looking. Chances are, will never need to use it for serious, or need to reload it, but still a good thing to be able to do well.