Here's my opinion.
I think the specialty "defense" rounds that I've seen for the 410 pistols are unproven.
As far as I know - no one has run these through gelatin tests or anything. No predictors for effectiveness.
Some of them look ridiculous. Some of them SOUND ridiculous!
I am betting that people would probably get the best results with either #1 Buck or #0 Buck.
As far as mixing these hybrid loads... like #2 and #4, I think what people eventually will find is that these mixed loads will create a gruesome wound, albeit a shallow one, but probably the shot is not going to penetrate the requisite depth to damage vital tissue which is the best way to assure incapacitation.
Does the PDX come in 3" shells ? I've only seen in in 2.5
Your wife's 410 doesn't have rifling does it? I would say stick with standard 410 shotgun ammunition. What you've got loaded now is probably as effective or more so than any of the specialty rounds being made for the Judge / Governors. The 410 is limited and there is no magic bullet. There is a lot of buzz over these 410 handguns, but they don't beat the laws of physics. I think the slick advertising makes them look like a mini 12ga. In reality it doesn't matter if you are sending a 45cal projectile or a 1/2 oz group of lead balls out the end of it. There is only so much the 410 can do.
I do think though that #1 and #0 probably would be the best bet.
I think you have 1/2 oz of shot, so you get around 5 pellets of #1 Buck, 4 pellets of #0
I would say it's like getting shot by a .32 four times.
Probably slightly more effective in 3" shells.
The problem is - I don't think anyone makes 410 ammo with #1 or #0 Buck