IMO the .357 145 grain Win STHP is an excellent personal defense load. It offers a good balance of penetration and expansion. It has much less blast than full-power 125 grain magnum loads, and recoil is not as severe as some other magnum loads.
IIRC, the FBI used to issue this load for those approved to carry magnum ammo in their duty revolvers.
It is fully jacketed, and there is no exposed lead. In fact, I don't think any STHP has exposed lead, in any caliber.