Let's be realistic, factory ammo for anything but .22LR and 9mm is expensive. Too expensive to use in sufficient quantity to become proficient with any chambering. The .357 is overrated. Whichever you choose, I suggest you reload. The .45Colt, while not my favorite, is a very potent chambering, even in a Colt SAA or replica. A 250gr cast bullet at 900-1100fps is much more consistently effective on game than any .357 load and it will do so with a lot less muzzle blast and noise. The guns are also lighter and balance better. My .38Spl SAA is a full 6oz heavier than my .45 version. However, when all is said and done, I'd rather have a .44Spl.