One concern that I have heard for using .357 Magnum for home defense is the fact that it is a supersonic round, and using it, especially indoors, would probably cause permanent hearing damage. While it's better to be deaf than dead, a subsonic round such as .45 ACP or its ballistically equivalent .44 Special may be something to consider - big, slow rounds that make big holes.
That's not to say that the .357 Magnum isn't an excellent manstopper. Obviously it is, but you may want to consider if you need to use it, the implications of discharging a supersonic round indoors.