The 110gr is a good choice, but if you ever have to fire that thing indoors, you will most certainly have hearing damage.
Also, in .357, muzzle flash is a big issue. Firing in low light conditions will certainly effect your night vision, it may even render you temporarily blind.
For home defence, you might want to consider .44spl, or .45 LC, or even .45acp sometime in the future.
To answer your question, the 110gr. is a good choice if penetration is an issue. I too have a GP-100 and Win. 110gr. is what I load all the time. The 125gr. is a serious boomer, especially indoors. Safety slugs maybe another good option, but expensive!!!
For tactical superiority, you might want to consider a .38spl. The FBI load is an excellent choice. The Rossi and Taurus revolvers I use for Home "D" is what i load. At those distances, and good shot placement, the FBI load is good enough.
Hell if you do have to shoot anybody, the .38 will look better in court when you get sued by the punks family.
Power is good, but be practicle in your choice and examine all the possibilities.
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"By His stripes we are healed..."
PeterGunn
[This message has been edited by PeterGunn (edited July 28, 2000).]