The .35 Whelen has been my go to hunting rifle for 20 years. Have killed 8 different species of big game with a 250 grain Nosler Partition at 2550 FPS, it works and works extremely well. A pile of deer both mulie and whitetail, a few black bears, a nice grizzly, a muskox, couple moose and caribou, wolf, it works well on the large stuff without being ridiculous on deer.
I have many rifles in quite a few chamberings, .270, 30-06, 300 Weatherby, 375 H&H, etc but I usually take the Whelen.