Some years ago, there were reported problems of Ruger Blackhawk .45 Colts having undersized throats. If yours has this problem, the only solution is to have the throats reamed. If your throats are .450", that's going to be the diameter of the bullet when it enters the forcing cone.....and the result is leading and poor accuracy.
It's easy to check, place a .452" bullet in the cylinder and push it through and out the front. If there is resistance, use a micrometer and measure the slug. If there is no resistance, you may have oversized throats.
The bottom line is that throat diameter determines correct sizing, not bore diameter.
I own both a 1980's BH .45 Colt convertible and a circa 2006 SBH Hunter, and both have .4525" throats and .4515" bores. I size all my cast boolits .452", and they shoot better than I can hold.