Erik. I guess I am a one load per rifle type of guy. I have a tendancy to make up what I call "working loads" for my rifles. I'll plat around with other loads, but when I hunt, I use the "working load". For .308, it is with a 165 gr. bullet, the 30-06, a 180 gr. bullet and in .300 Win. Mag. a 200 gr. bullet. A form of the K.I.S.S.principle.
I don't like shooting past 200 yard, unless it is to stop a wounded animal. So, for most purposes, the 30-06 would be my choice. One, it kicks less, and generally can weigh less than the .300's, although mine weighs only 7.5 pounds, scope sling and full magazine. Most are heavire though. Another is ammo. If you should run out while on a boondocks hunting trip, I'll wager you'll have a better chance of finding ammo for the "06" than the magnum.
I'll admit that when I go hunting, I'll be packing some exotic round, like a wildcat .375 Mag. or my .35 Whelan, but my backup rifle is always a 30-06. You can take that to the bank.
Paul B.