The New Vaquero is built on the old original .357 Blackhawk frame size, (with fixed sights and New Model transfer bar, of course) and is only a little bigger than a Colt. It is NOT recommended for the magnumized .45 Colt loads often shot in Original Vaqueros on the big frame. There are already reports of some being wrecked by super hot loads that an Original Vaquero would have handled.
If you are in the habit of overloading .45 Colt, better buy now, the Original Vaquero is being dropped from production.