Sounds like something changed, so the problem is to find out what that was. Something could have slipped, loosened or changed position slightly. Did you do anything at all to the rifle after it shot those good groups? I'd guess it was the scope, but you said you tried another scope (was it a good scope?) and had the same problem. So, I'd start at zero. I'd pull the action out of the stock (and is it wood or synthetic and have you been in the rain?) and have a look at the stock and bedding points. And do you need that pressure point? Then I'd put it all back together again and tighten the action screws per the manufacturer. Then I'd clean the barrel real good again. If that didn't do the trick, I'd pull the scope and mounts off and reinstall all of that carefully. If you've been shooting reloads, I'd try some factory loads to see where and how they shoot. And if none of that helps...well...we're back to knowing that something changed but we still don't know what that was. Good luck.