The Sierra manual uses 2.650" for both of their 100 grain bullets. That's a going to be a good starting point. Different gun makers use slightly different reamer designs, with the result that some throats are longer than others. Additionally, depending upon how much wear the reamer had on it when your chamber was cut, your freebore and neck area may be wider or narrower than the next rifle from the same maker had, and that affects how much gas bypasses the bullet before it gets to the throat which affects the peak pressure reached, and with that, the barrel time and point of release in the muzzle deflection induced by recoil moments and pressure distortion during firing.
I'm not trying to overwhelm you with the multitude of influences and factors that affect accuracy, but rather to give you some idea why handloaders commonly say, "every gun is a law unto itself". That just means what the next fellow's rifle likes best often does not match what your's likes best. Seating depth is certainly one of the things no two guns can necessarily be counted upon to agree on exactly.
Berger has an article on this that is worth your time, having found their own VLD bullets will shoot best in some rifles jamming the lands in the throat, but in others may need to have as much as 0.150" of jump to the throat.
That said, you can generally find one load that does pretty well in most rifles. This is what Dan Newberry calls a chocolate ice cream load, based on the idea that no matter what flavor of ice cream people consider their favorite, almost everyone at least likes chocolate pretty well. So what you need is a method of finding such loads. Newberry likes
his OCW method. He lists a load for 100 grain bullets of 42.2 grains of IMR 4831. The only IMR 4350 load he lists as an OCW load is for a 75 grain bullet.