I've worn out several rifle barrels, and I have 4 .243s. "Wear out" is also an undefined term. For me, if a settled barrel is shooting 1/2" after about 100 rounds, then I'll think about a set-back or rebarrel when the group size exceeds 1". For a .243, that is going to be around 2000 rounds, +/- 500 depending on factors. Those factors are the bullet, how hot you get it and what powder you use.
I have a 15 year old .260 Rem barrel that will make it to 10K, but it started life as a 24" barrel and it is now 21.5 inches. It has been cut back, rechambered, and recrowned.