I guess you're looking for a "full size" .22 rifle, when you say "compatible"?
I don't know of any southpaw versions, but suchlike as the old Remington 550 semi-auto comes close to filling the bill. (Is the 552 the followup to this?)
Years ago, Walther made a heavy-ish barrelled .22 semi-auto. (Tricky little deal; magazine fed. If you put the bolt handle in the "down" position, it functioned as a single-shot.) Per Fjestad, they're only worth around $150 to $200. Accurate as all get-out...
FWIW, Art