The .22 lr is much more tolerant of an inconsistent grip with the strong hand. The more recoil, the more important it is to keep an absolutely consistent grip from shot to shot.
A .22 allows a more sloppy grip in that regard. By varying my hand position, even slightly, I can move my groups 4-5" at 25 yds, and open my groups by the same amount with a heavy caliber hand gun.
Many have said that the three most important factors for accuracy in a hand gun are:
1. Sight picture with focus 100% on the FRONT SIGHT. This allows front sight and rear sight in proper alignment.
2. Trigger control. Manipulating the trigger in such a way so as not to disturb the sight picture achieved in #1. For many that means a straight back trigger press, with no hesitation "when things look just right", while allowing the shooter's normal amount of wobble.
3. Consistent Grip. Each time the piece is handled, a FIRING GRIP is taken, with the same position on the grips and with the same amount of force exerted by the fingers and palm.
Achieving those three points will allow you to shoot to the gun's mechanical and ammunition limits. No one gets this good, but some do approach it.
Rod