Ironic
Isn't it ironic that the venerable 222 is talked about as yesterday's bubblegum in other posts, and the 221 Fireball is the toast of the town? Your Fireball and the 222 are far too close to split hairs over, although advantage goes to the 222. And the difference between the 223 and 222 is also small, but the 223 is a little better at everything, although its neck is a little short.
Factoid:
The 30-06 is arguably a perfect design. The 222 Rem dimensions were originally determined by reverse projecting a 30-06 image down to 22 caliber. Both are the epitome of efficiency. Your 221 relates to the 222 like the 308 does to the '06. They're all excellent. Just beware of gunwriters' hype about "great" new cartridges.