There are adapters that allow firing .22 LR in a .22 Mag, so if you have a double action that doesn't have a spare .22 LR cylinder you could shoot the cheaper ammo. I'm generally not against shooting .22 LR in a Magnum chamber, except in revolvers because even in a non revolver you lose pressure due to pressure being exerted to expand the case more, but in a revolver you also have the cylinder gap which adds to more pressure loss.
Because of this, I'm generally averse to buying .22 Magnum DA revolvers, except maybe the Taurus Trackers as they have the .22 LR cylinder. For single actions, they all seem to come with both cylinders.