You are good out to 200 yards for whitetail sized game. Deer in the weight range up to 200 pounds are regularly taken with the 22-250 around here. If you were to try it for deer, I would use at least 55gr soft points. You can use up to 60gr, maybe 62gr(my experience),with most standard twist barrels but any thing heaver will do best with a tighter twist such as a 1:9 twist. Soft points tend to work best for the larger game (Hog, Coyote, and Deer). As stated before shot placement is critical to a fast kill, but not so different from where (Heart, Lung, Neck, Spine, and Head) any other caliber should be placed.