When my Taurus 651 titanium is loaded up with six .357 125grain JHPs, it weighs 19.3 ounces, although please note that I changed the stock grips to Uncle Mike's boot grips, so your weights may vary.
I find these painful to shoot, and shoot no more than 5-10 rounds at any one session. In contrast, however, the .38 +P Speer Gold Dots 135 grain JHP optimized for the short barrel, is easier to shoot, and that is my standard carry load.