Here is a clip from the this web site:
http://www.chuckhawks.com/ammo_by_anonymous.htm
I am not sure I agree with the comments fully, I thought it was interesting reading. I, for one, am sold on 00 buck. Here is the first portion of the text regarding shotguns:
SHOTGUN AMMUNITION BY CALIBER (Gauge)
The shotgun is the ne plus ultra of manstoppers. No other weapon will put a man down as reliably as a shotgun, and no other weapon is as likely to hit your opponent as a shotgun filled with buckshot. No doubt you have heard a lot of nonsense about the lethality of "assault rifles" and "Uzi sub-machine guns" and the like. The fact is that the shotgun is by far the deadliest and most effective firearm for short-range personal defense. For example: an Uzi or Heckler & Koch sub-machine gun has about 340 ft-lbs. of impact energy - a 12 gauge shotgun has 2500 to 3100 ft-lbs. of impact energy, and it is a heck of a lot easier to hit your target with a shotgun than a sub-machine gun.
The shotgun is not a magic weapon that will slay all foes, but it is simply the most effective man-stopping firearm yet devised. I invoke the Ascended Master, Massad Ayoob: "It is perhaps the most efficient close-range killing machine in the world's arsenal of small arms." For a discussion of the shotgun's strengths and weaknesses I refer all interested parties to Ayoob's excellent and comprehensive book 'The Truth About Self-Protection' (truly the best $8.95 investment you'll ever make), which discusses every element of self-defense from locks, chemical sprays and alarms to defensive driving, firearms and defending yourself against dogs. A more in-depth treatment of the issue may be found in Ayoob's book-length volume on shotgun technique, 'Stressfire II: Advanced Combat Shotgun'.
A Note On Terminology
Shotgun ammunition falls into three general categories:
BUCKSHOT - shell loaded with large-diameter lead balls (.24" and up) used for big game hunting and self-defense. The number of pellets in 12 gauge buck-shot varies from eight .36" balls in "000 buck" to 27 .24" pellets in "#4 buck". Buckshot ratings are archaic and hard to understand (as are shotgun specifications and ammunition in general), but thankfully there isn't much you need to learn. Simply write down the recommended loads, walk into your local gunshop and announce your desired ammunition (note that "00" is pronounced "double ought" and "000" is pronounced "triple ought." Don't say "zero zero" or "oh-oh-oh buckshot" in front of gunshop employees - they will snicker and mock you cruelly behind your back). Then practice with both your selected defense load and low-cost birdshot to fully familiarize yourself with the operation of your gun and its terminal performance (e.g. patterns at various distances, the startling effects of buckshot on ballistic melons).
BIRDSHOT- small-diameter pellets used for bird hunting. Its stopping power is poor, except when used at very close range - out to 20-30 feet. For that reason it is not generally recommended, except for home defense use.
SLUGS are solid lead bullets for shotgun use. These are big, heavy, fat hunks of soft lead that have enormous stopping power (e.g. a typical 12 gauge slug is .73" caliber and weighs 438 grains - a 9mm bullet is .355" and 115 grains). Use of slugs ruins the shotgun's main advantage - superior hit probability - as slugs must be carefully aimed to be effective. It is important to remember, however, that shotguns must be aimed with shot, too - do not for a minute think that you can simply point your shot-loaded shotgun at the foe and let loose. Shotguns must be skillfully aimed and fired just like hand-guns and rifles. The shotgun is simply more likely to hit the attacker.
.410 Gauge
None of the above really applies in this weak caliber. The .410 is only a half-way decent manstopper with slugs. Choose the Federal Classic (F412RS) or Winchester Super-X (X41RS5) 1/5 ounce (88 grain) hollowpoint slug. Never use birdshot. American Derringer Corp. has produced an odd buckshot load for the .410 (withthree 000 pellets), and I advise you to ignore it. Lose the .410 and buy a 20 gauge pump shotgun.
20 Gauge
The 20 is an excellent self-defense caliber, particularly for those who dislike the recoil of the 12 gauge. I recommend the 20 gauge over the more popular 12 for home defense. Choose the 20 gauge 3" shell Federal "Classic" #2 buckshot (F207-2-5PK) with 18 pellets, or the Winchester "Double XX" Magnum #3 with 24 pellets (X203C3B). If your gun cannot accept 3" shells choose the Remington #3 with 20 pellets (SP20BK5PK-3). All of these loads provide definitive short-range stopping power.
I specifically recommend the 20 gauge for women and recoil-sensitive men who dislike the blast and recoil of the 12 gauge. "Delivering roughly the ballistic force of two .44 Magnum rounds at once," comments the knowledgeable Ayoob, the 20 "delivers 75% of the lead for only 50-60% of the recoil". Many police departments have found their officers shoot much more accurately in realistic training exercises with the lighter-kicking but still potent 20 gauge.
If you are new to shotgunning and considering getting one for self-defense I strongly urge you to buy the reliable and reasonably-priced "Mossberg 500 Special Purpose" 18.5" barrel 20 gauge pump shotgun (catalog #50451). This tried-and-true workhorse is the standard shotgun of the U.S. Armed Forces and costs a little over $200. You'll be much happier with the lighter-kicking 20 gauge than the 12 gauge version used by the military, and - most importantly - you'll shoot the 20 more accurately and rapidly.
For an in-depth look at the 20-versus-12 gauge issue I recommend all shotgun owners (and potential shotgun owners) read 'Stressfire II: Advanced Combat Shotgun' by Massad Ayoob. Perhaps I am beginning to sound like a broken record on the theme of Ayoob's books, but once you've read them you'll understand why I recommend them so highly (and repeatedly). Note: Ayoob dislikes the 20 gauge Remington 870 pump shotgun and recommends you choose the Mossberg 500 in 20 gauge for general self-defense and home-defense use. So do I.
For ultra-close range home defense birdshot will do the trick. Choose any #4, BB or larger high brass lead hunting load, and have the balance of the magazine filled with #3 buck in case the birdshot doesn't put them down fast enough.
Avoid slug use in 20 gauge; you are better off defending yourself with buckshot. If you must use slugs, pick the Dynamit/Nobel or Federal "Classic" (F203-RS) rifled slugs. Using slugs requires careful aiming and rifle sights: few 20 gauge shotguns have the latter.
16 Gauge
The 16 has slipped in popularity with Americans. As a result, no shotguns made specifically for defense are available in 16. If you have a sporting 16, however, it can do double duty as a great defense gun. Choose the Federal "Classic" #1 (F164-1) or the Remington #1 (SP16BK-5PK) buckshot load.