All hands are the same, but different. That's why they have different combinations.
Not for me, thanks. I'd like to get my hand inside the magazine well if I can for a good, tight grip (as Professor John Skaggs at Chapman Academy learnt me).
Depends on your hand. I have thick hands, but size medium. While they are great for a fist, I will never be Jeff Beck with a guitar. (Maybe I could stretch them out)?