If one were to be tried for a defensive shooting in a Criminal court, I doubt if the ammunition used were to ever come into question.
But please be aware, that is not the only court in which you could be subjected to.
There is also civil court. Though you cannot be thrown in the slammer for a "guilty" verdict in such courts, it may be just as devastating economically for one's family.
In civil court, regardless if you were found "Not Guilty" or even "Innocent" in criminal court, you could still stand lose all that you have and possibly a garnishment against all future income (for the cost of professional life-long medical care of the maimed "victim" of one of your nasty "nuclear-armageddon-manslayer" defensive rounds).
All you would need to stack the cards against you in some cases may be a judge that watches The Rosie Show while drinking his coffee every morning and a "I Love My Kitty" bumper sticker on the back of his Subaru.
Then again, you may not be sued for your choice of ammunition.
However, here you have a Risk vs Rewards issue.
One must question whether their defensive handloads offer any tangible performance over factory premium defensive loads.
Personally, I think I'll let the buck stop at Federal. I honestly believe Hydra-Shoks are easily sufficient for the task.