CAUTION: The following post includes loading data beyond or not covered by currently published maximums for this cartridge. USE AT YOUR OWN RISK. Neither the writer, The Firing Line, nor the staff of TFL assumes any liability for any damage or injury resulting from the use of this information.
Jjavedas,
Comparing Hodgdon data to QuickLOAD by adjusting QuickLOAD's powder model to better match Hodgdon's measurements, it looks to me like 150 to 180-grain jacketed bullets over 3.2-3.5 grains of Clays will give you jacketed target velocities with pressures in the .45 Auto target load pressure range. Lead bullets may be loaded lower. I don't know details like the lengths of your barrel and cylinder and be cautioned this is not data tested by me or by Hodgdon, so you have to watch out for loads that stick in the barrel due to more gas bypass and barrel/cylinder gap pressure bleed-off than I can accurately allow for. Be careful never to shoot another round into a bullet stuck in the bore, as that can be the end of your gun. If you have a chronograph, see if you can tune loads to be 750 fps-ish from a 4" revolver barrel and 800 fps-ish from a 6" barrel.