With the .22/250 the standard 1:14 twist is best for small projectiles, up to 50gr, for bullets up to and including the 60gr (i.e. Nosler Partition), you are best to use a 1:12 twist. The fast twist 1:8 & 1:7 are designed to shoot the long 80gr Matchking and other VLD bullets.
The big problem with a fast twist barrel and small bullets (which will have a very high muzzle velocity) is that the velocity obtained with give an extremely high rpm rate to the bullet, with the chance that the bullet will disintegrate under the rotational forces and not reach the target.